Cell Cycle–Dependent Translation Initiation
نویسندگان
چکیده
منابع مشابه
Translation Initiation System
AhtractRedundancy occurs naturally within RNA and DNA sequences [l]. The existence of tandem repeats, and sequences such as the Shine-Dalgarno sequence, the Pribnow box and the TATA box, leads us to believe that cellular communication systems use some method of coding to recognize valid information regions within a nucleotide sequence and correct for “transmission” errors such as mutations. In ...
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Two studies by Meyer et al. and Wang et al. demonstrate a role for m(6)A modification of mRNA in stimulating translation initiation. These findings add to the growing number of diverse mechanisms for translation initiation in eukaryotes.
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Sixteen single point mutations near the beginning of the lacZ gene have been isolated and their effect on lacZ expression has been measured. Five mutations were obtained that alter a potential stem-and-loop structure in the messenger RNA that masks the initiation codons. Formation of this stem-and-loop is a result of transcription of DNA sequences introduced during the cloning of the lac regula...
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tion of eIF4E can diminish its interaction with eIF4G and Once mRNA is transcribed from DNA, its level of expresthe cap structure. In fact, the appearance of dephossion is dependent upon the efficiency of a number of phorylated eIF4E correlates with the loss of cap binding interconnected cellular processes. These include polyactivity and cap-dependent translation in G2/M cells adenylation and s...
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It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA. Therefore, regulation of translation initiation is likely to be intimately involved in modulating ...
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ژورنال
عنوان ژورنال: Cell
سال: 2000
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80834-x